Synthesis and characterization of Some Transition Metals complexes with N-(4-phenylthiazol-2-yl) benzamide and evaluation of its biological activity

For the synthesis of the new N-(4-phenylthiazol-2-yl) benzamide ligand, 4-phenylthiazol-2-amine, and benzoyl chloride in a 1:1 molar ratio was condensed in ethanol with ammonium acetate. For creating the Zn (II), Ni (II), Mn (II), and Co (II) complexes, the above-mentioned ligand was directly reacted with metal chlorides in an ethanolic medium at a molar ratio 1:1 and 2:1 (Ligand: Metal). Determination of the elemental composition of a substance, spectral studies. The produced complexes were characterized using (FTIR, UV/visible), Proton-NMR and conductivity. The findings demonstrated octahedral and tetrahedral geometric availability linked to the central ion, along with an inhibitory effect on the growth of various bacterial strains, such as Escherichia coli, Staphylococcus aurous, Bacillus, and Klebsiella pneumonia. Complex (9) with the structure [Cu(L)₂Cl₂] has a higher effect on different bacterial species than the other complexes, which had a lower effectiveness rate, according to the results.