The Correlation between Genetic Variation for SNCA Gene with Parkinson’s Disease

The purpose of the present research was to investigate the relationship between the variation of SNCA sequences and Parkinson's syndrome by collecting 120 specimens of blood from both patients as well as normal people who visited Ibn Sina Teaching Hospital in Mosul from Dec to June 2023-2024. The specimens were separated between different categories, including the Parkinson's (patient) group donated symbol P, which contained thirty specimens split into two distinct age-based subgroups, P1 (ages 50-65) and P2 (ages 66-80). Each had 15 blood samples, and the Parkinson's family record group contributed symbol F had thirty specimens of persons around the ages of 25 and 50 as well to controls group C, which had sixty specimens of people who were healthy split into three subgroups: C1 (50-65 years old) C2 (ages 66-80) and subgroup C3 (ages 25-50). Results of our study After comparison between these groups showed for the first time mutation in different location in the SNCA gene parts after specific primers designed in different parts of this gene utilized PCR technique. Most of these mutations are point mutation in the amplicon sequences of the specific gene parts in extracted DNA from blood samples of family group (F) and Parkinson’s group (P) compared with the healthy group (C) blood samples.

This research concluded according to its results that SNCA gene had an important role in the Parkinson’s disease early diagnostic due to the point mutation that occurred in family history group F which could be utilized as early diagnostic marker.