Isolation and Studying The Active Compounds from Ginger (Zingiber officinalis) in Normal and Diabetic Rabbits

The study was included isolation of cold proteinous and non-proteinous extracts of Zingiber officinals roots. The study also comprised the isolation and studying the proteinous compounds, using gel filtration technique which produced two compounds A (M.wt 108542 D) and B (M.wt 3247 D). The proteinous and non-proteinous compounds were administrated interaperitio-neally. After one week from the treatment, the results were indicated that the proteinous precipitate and (B) proteinous compound at the doses (150,75) body weight which were caused a significant decrease (P < 0.05) in serum glucose (glu), total cholesterol (TC), total lipid, LDL-C levels , with an associated significant increase (P<0.05) in serum HDL-C level, Glutathion (GSH) and superoxide dismutase (SOD) enzyme activity in liver, kidney and heart tissues, in normal and alloxan-induced diabetic rabbits. Finally, It was suggested the proteinous compound B has antidiabetic and antioxidative stress effect in normal and diabetic rabbibts.