Development of Spectrophotometric Method for the Determination of Metoclopramide. HCl in a Pharmaceutical Preparations

This paper includes a development of spectrophotometric method for the determination of metoclopramide.HCl. The method involves the diazotization of metoclopramide.HCl and coupling with pyridoxine. HCl, to form an intense orange colored, water-soluble and stable azo-dye which shows a maximum absorption at 470 nm. Beer's law is obeyed over the range 0.5-30 g/ml metaclopramide. HCl with a molar absorptivity of 1.98*104 L.mol-1.cm-1, The average recovery is 99.27% and relative standard deviation of 0.124 to 0.778%. This method has been applied successfully to the determination of metoclopramide.HCl in pharmaceutical preparations.