Synthesis of some Pyrimidine-2-one and Pyrimidine-2-thione Compounds

An efficient synthesis of chalcones (1-7) was achived by condensation of substituted benzaldehyde with substituted acetophenone in ethanolic sodium hydroxide (50%).The chalcones were reacted with urea and thiourea to give the pyrimidinones(8-14) and pyrimidinethiones(15-21) respectively. All the prepared compounds were confirmed by the available physical and spectral methods.