Irradiation Assisted Synthesis and Antifungal Activities of Some Mannich Bases

To eliminate the use of solvent during the course of reaction and to decrease the reaction time in addition to enhanced the yield in synthesis of some Mannich bases 5-((5-(Aryloxymethyl)-1,3,4-thiadiazol-2-ylamino)(phenyl)methyl)pyrimidine-2,4,6 (1H,3H,5H)-trione (2a-h),the reaction was carried out under microwave irradiation of equimolecular mixture of 2-amino-5-aryloxymethyl 1,3,4 thiadiazoles (1a-h), benzaldehyde and barbituric acid, using magnesium sulfate as absorption support.
In conventional method the attempts to react amine(1a)with aldehyde to form Schiff base and the reaction of this base with barbituric acid did not succeed.
The structures of these compounds were confirmed by IR Spectrophotometer. All these bases were screened for their antifungal activity against Aspergillus flavus and found to possess weak activity